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Adrenergic Receptor b2 Activation by Stress Promotes Breast Cancer Progression through Macrophages M2 Polarization in Tumor Microenvironment
junfang qin1,2, fengjiao jin1, ning li1, haitao guan1,2, lan lan3, hong ni1,2, yue wang1,*
1School of Medicine and 2State key laboratory of medical chemical biology, Nankai University,
3Tianjin Cancer Hospital, Tianjin Medical University
Stress and its related hormones epinephrine (E) and norepinephrine (NE) play a crucial role in tumor progression. Macrophages in the tumor microenvironment (TME) polarized to M2 is also a vital pathway for tumor deterioration. Here, we explore the underlying role of macrophages in the effect of stress and E promoting breast cancer growth. It was found that the weight and volume of tumor in tumor bearing mice were increased, and dramatically accompanied with the rising E level after chronic stress using social isolation. What is most noteworthy, the number of M2 macrophages inside tumor was up-regulated with it. The effects of E treatment appear to be directly related to the change of M2 phenotype is reproduced in vitro. Moreover, E receptor ADRb2 involved in E promoting M2 polarization was comprehended simultaneously. Our results imply psychological stress is influential on specific immune system, more essential for the comprehensive treatment against tumors.
Abstract, Accepted Manuscript(in press) [Submitted on January 14, 2015, Accepted on March 6, 2015]
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