Adrenergic Receptor b2 Activation by Stress Promotes Breast Cancer Progression through Macrophages M2 Polarization in Tumor Microenvironment |
junfang qin1,2, fengjiao jin1, ning li1, haitao guan1,2, lan lan3, hong ni1,2, yue wang1,* |
1School of Medicine and 2State key laboratory of medical chemical biology, Nankai University, 3Tianjin Cancer Hospital, Tianjin Medical University |
Abstract
Stress and its related hormones epinephrine (E) and norepinephrine (NE) play a crucial role in tumor progression. Macrophages in the tumor microenvironment (TME) polarized to M2 is also a vital pathway for tumor deterioration. Here, we explore the underlying role of macrophages in the effect of stress and E promoting breast cancer growth. It was found that the weight and volume of tumor in tumor bearing mice were increased, and dramatically accompanied with the rising E level after chronic stress using social isolation. What is most noteworthy, the number of M2 macrophages inside tumor was up-regulated with it. The effects of E treatment appear to be directly related to the change of M2 phenotype is reproduced in vitro. Moreover, E receptor ADRb2 involved in E promoting M2 polarization was comprehended simultaneously. Our results imply psychological stress is influential on specific immune system, more essential for the comprehensive treatment against tumors.
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Abstract, Accepted Manuscript(in press) [Submitted on January 14, 2015, Accepted on March 6, 2015] |
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