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GATA4 negatively regulates bone sialoprotein expression in osteoblasts
Insun Song3, Byung-chul Jeong5, Yong Jun Choi4, Yoon-Sok Chung4, Nacksung Kim1,2,*
1Pharmacology and 2Biomedical Sciences, Chonnam National University Medical School,
3Medical Genetics and 4Endocrinology, Ajou University School of Medicine,
5Pharmacology and Dental Therapeutics, Chonnam National University
Abstract
GATA4 has been reported to act as a negative regulator in osteoblast differentiation by inhibiting Dlx5 transactivation of Runx2 via the attenuation of the binding ability of Dlx5 to the Runx2 promoter region. Herein, we determine the role of GATA4 in the regulation of bone sialoprotein (Bsp) in osteoblasts. Overexpression of Runx2 or Sox9 induced Bsp expression in osteoblastic cells. Silencing GATA4 further enhanced Runx2- and Sox9-mediated Bsp promoter activity, whereas GATA4 overexpression down-regulated Bsp promoter activity mediated by Runx2 and Sox9. GATA4 interacted with Runx2 and Sox9. GATA4 attenuated the binding ability of Runx2 and Sox9 to Bsp promoter region. Our data suggest that GATA4 acts as a negative regulator of Bsp expression in osteoblasts.
Abstract, Accepted Manuscript(in press) [Submitted on February 15, 2016, Accepted on March 11, 2016]
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