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Identification of a neural pathway governing satiety in Drosophila
Soohong Min1, Soohong Min1, Jongkyeong Chung1,*, Jongkyeong Chung1,*
1National Creative Research Initiatives Center for Energy Homeostasis Regulation and 1National Creative Research Initiatives Center for Energy Homeostasis Regulation, Institute of Molecular Biology and Genetics and School of Biological Sciences, Seoul National University, 599 Gwanak-Ro, Gwanak-Gu, Seoul 151-742, Republic of Korea
Abstract
Satiety cues a feeding animal to cease further ingestion of food for protecting from excessive energy gain. Impaired control of satiety is often associated with feeding-related disorders such as obesity. In the present paper, we reported the identification of a neural pathway that expresses myoinhibitory peptide (MIP) critical for satiety responses in Drosophila. Targeted silencing of MIP neuron activity strikingly increased body weight (BW) through elevated food intake. Similarly, genetic disruption of the gene encoding MIP also elevated feeding and BW. Suppressing MIP pathway behaviorally transformed satiated flies to feed like the starved ones with augmented sensitivity to food. Conversely, temporal activation of MIP neuron markedly reduced food intake and BW, and blunted the sensitivity of starved flies to food as if they have been satiated. Shortly after termination of MIP neuron activation, the reduced BW was reverted to normal level with a strong feeding rebound. These results consistently suggest the switch-like role of MIP pathway in feeding by controlling satiety.
Abstract, Accepted Manuscript(in press) [Submitted on March 7, 2016, Accepted on March 7, 2016]
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