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Human adipose-derived mesenchymal stem cells in a spheroid improve recovery in a mouse model of elastase-induced emphysema
Ryeon Jin Cho1,#, You-Sun Kim1,2,#, Ji-Young Kim2, Yeon-Mok Oh1,2,3,*
1University of Ulsan College of Medicine, Seoul, Republic of Korea,
2Asan Institute for Life Science, Seoul, Republic of Korea,
3Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Disease, Asan Medical Center, Seoul, Republic of Korea
Abstract
Background/Purpose: Emphysema, a pathologic component of chronic obstructive pulmonary disease, causes irreversible destruction. Many researchers have reported that mesenchymal stem cells can regenerate lung tissue after emphysema.
Methods: We evaluated if spheroid human adipose-derived mesenchymal stem cells (ASCs) showed greater regenerative effects than dissociated ASCs in elastase-induced emphysema mice. ASCs were administered via an intrapleural route.
Results: Mice injected with spheroid ASCs showed improved regeneration of lung tissue, increased expression of growth factors such as FGF2 and HGF, and a reduction in proteases with an induction of protease inhibitors when compared with mice injected with dissociated ASCs.
Conclusions: Our findings indicate that spheroid ASCs show better regeneration of lung tissue than dissociated ACSs in elastase-induced emphysema mice.
Abstract, Accepted Manuscript(in press) [Submitted on June 16, 2016, Accepted on October 14, 2016]
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