Mechanosensitive モ-catenin signaling regulates lymphatic vascular development |
Boksik Cha1, R. Sathish Srinivasan1,2,* |
1Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA, 2Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA |
Abstract
The Wnt/モ-catenin signaling is an evolutionarily conserved pathway that plays a pivotal role in embryonic development and adult homeostasis. However, we have limited information about the involvement of Wnt/モ-catenin signaling in the lymphatic vascular system that regulates fluid homeostasis by absorbing interstitial fluid and returning it to blood circulation. In this recent publication we report that canonical Wnt/モ-catenin signaling is highly active and critical for the formation of lymphovenus valves (LVVs) and lymphatic valves (LVs). モ-catenin directly associates with the regulatory elements of the lymphedema-associated transcription factor FOXC2 and activates its expression in an oscillatory shear stress (OSS)-dependent manner. The phenotype of モ-catenin null embryos was rescued by FOXC2 overexpression. These results suggest that Wnt/モ-catenin signaling is a mechanotransducer that links fluid force with lymphatic vascular development.
|
Abstract, Accepted Manuscript(in press) [Submitted on July 15, 2016, Accepted on July 15, 2016] |
|