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Zinc(II) Ion Promotes Anti-inflammatory Effects of rhSOD3 By Increasing Cellular Association
Yoon-Jae Jeon1,#, Younghwa Kim2,#, Kang Ryu3, Tae-Yoon Kim1,*
1Laboratory of Dermato-Immunology, Catholic Research Institute of Medical Sciences, College of Medicine,
2Department of Emergency Medical Technology, Kyungil University,
3RNS BIO
Abstract
Recently, we demonstrated that superoxide dismutase 3 (SOD3) is a strong biomedicine candidate. SOD3 accomplished anti-oxidant function without cell penetration and inhibited inflammatory responses via non-enzymatic functions. SOD3 has the heparin binding domain associating cell surface. Interestingly, we have found that Zn2+ promotes transduction effects of recombinant human SOD3 (rhSOD3) by increasing uptake via heparin binding domain (HBD). We showed an uptake of rhSOD3 from media to cell lysate via HBD, resulting in an accumulation of rhSOD3 into the nucleus, which is promoted by the presence of Zn2+. As a result, we showed the increased inhibitory effects of rhSOD3 on NF-kB and STAT3 signal under the presence of Zn2+ which is elevated association of rhSOD3 into the cells. These results suggested that the optimized procedure can help to enhance the inflammatory efficacy of rhSOD3, as a novel biomedicine.
Abstract, Accepted Manuscript(in press) [Submitted on August 25, 2016, Accepted on November 18, 2016]
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