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Polymer brush: The promising grafting approach to scaffolds for tissue engineering
Woonjung Kim1, Jongjin Jung1,*
1Department of Chemistry, Hannam University, Daejeon 340-54, Korea
Abstract
Polymer brushes are the soft material units tethered covalently on the surface of scaffolds, which induce the functional and structural modification of a substrate's properties. Due to its facile fabrication, usability of various polymers, ECM (extracellular matrix)-like structural features, and in vivo stability, this surface coating approach has attracted special attentions in the fields of stem cell biology, tissue engineering, and regenerative medicine. Here, we summarized polymer brush-based grafting approaches comparing SAM (self-assembled monolayer)-based coating method in addition to physico-chemical characterization techniques of surfaces such as wettability, stiffness/elasticity, roughness, and chemical composition mainly affecting cell adhesion, differentiation, and proliferation. We also reviewed recent advancements of cell biological applications of polymer brushes focusing more on stem cell differentiation and 3D supports/implants for tissue formation. It is estimated that cell behaviors on polymer brushes in the scale of nanometer length contribute to the systematic understandings of simultaneous effects toward cellular responses at its interface from polymers and scaffolds for promising platform designs.
Abstract, Accepted Manuscript(in press) [Submitted on September 29, 2016, Accepted on September 29, 2016]
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