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Neuron-specific expression of p48 Ebp1 during murine brain development and its contribution to CNS axon regeneration
Hyo Rim Ko1, Inwoo Hwang1, So Yoon Ahn2,3, Yun Sil Chang2,3,4, Won Soon Park2,3,4,#, Jee-Yin Ahn1,4,*,#
1Department of Molecular Cell Biology, Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine,
2Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea,
3Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul, South Korea,
4Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea
Abstract
P48 Ebp1 is expressed in rapidly proliferating cells such as cancer cells and accelerates cell growth and survival. However, its expression pattern and roles in central nervous system development have not been studied. Here, we demonstrated the spatiotemporal expression pattern of p48 Ebp1 during embryonic development and the postnatal period. During embryonic development, p48 Ebp1 was highly expressed in the brain. Expression gradually decreased after birth but was still more abundant than p42 expression after birth. Strikingly, we found that p48 Ebp1 was expressed in a cell type specific manner in neurons but not astrocytes. Moreover, p48 Ebp1 physically interacted with beta tubulin but not alpha tubulin. This fit with its accumulation in distal microtubule growth cone regions. Furthermore, in injured hippocampal slices, p48 Ebp1 introduction promoted axon regeneration. Thus, we speculate that p48 Ebp1 might contribute to microtubule dynamics acting as an MAP and promotes CNS axon regeneration.
Abstract, Accepted Manuscript(in press) [Submitted on November 14, 2016, Accepted on December 1, 2016]
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