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Vitamin C enhances the expression of IL17 in a Jmjd2−dependent manner
Mi Hye Song1, Varun Sasidharan Nair1, Kwon Ik Oh1,*
1Department of Pathology, Hallym University College of Medicine
Previously, we reported that vitamin C facilitates the CpG demethylation of the Forkhead box P3 (Foxp3) enhancer in CD4+Foxp3+ regulatory T cells (Tregs) by enhancing the activity of DNA demethylase, ten-eleven-translocation (Tet). However, it is elusive whether vitamin C affects other helper T cells lineages like T helper type 17 (Th17) cells which is related with Tregs. Here, we show that the expression of interleukin-17A (IL17) increases with the treatment of vitamin C, but not other antioxidants. Interestingly, the upregulation of IL17 was not accompanied by DNA demethylation in Il17 promoter and was independent of Tet enzymes. Rather, vitamin C reduced the trimethylation of histone H3 lysine 9 (H3K9me3) in regulatory elements of Il17 locus and the effects of vitamin C were abrogated by knockdown of jumonji-C domain-containing protein 2 (jmjd2). These results suggest that vitamin C can affect the expression of IL17 through modulation of histone demethylase activity.
Abstract, Accepted Manuscript(in press) [Submitted on November 21, 2016, Accepted on December 8, 2016]
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