microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor. |
Heejin Lee1,#, Hyosun Tak1,#, So Jung Park2, Yoon Kyung Jo2, Dong Hyung Cho2,#, Eun Kyung Lee1,*,# |
1Department of biochemistry, The Catholic University of Korea, 2Department of Gerontology, Graduate School of East–West Medical Science, Kyung Hee University |
Abstract
Mitochondrial play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated. In this study, we identified miR-200a-3p as a novel regulator of mitochondrial dynamics by targeting mitochondrial fission factor (MFF). We demonstrated that the ectopic expression of miR-200a-3p enhanced mitochondrial elongation, increased mitochondrial ATP synthesis, mitochondrial membrane potential and oxygen consumption rate. These results indicate that miR-200a-3p positively regulated mitochondrial elongation by downregulating MFF expression.
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Abstract, Accepted Manuscript(in press) [Submitted on January 14, 2017, Accepted on January 31, 2017] |
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