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Translation initiation mediated by nuclear cap-binding protein complex
Incheol Ryu1,2, Yoon Ki Kim1,2,*
1Creative Research Initiatives Center for Molecular Biology of Translation and 2School of Life Sciences, Korea University, Seoul 02841, Republic of Korea
Abstract
In mammals, cap-dependent translation of mRNAs is initiated by two distinct mechanisms: CBC-dependent translation (CT) and eIF4E-dependent translation (ET). Both translation initiation mechanisms share common features in driving cap-dependent translation; nevertheless, they can be distinguished from each other based on their molecular features and biological roles. CT is largely associated with mRNA surveillance, whereas ET is predominantly involved in the bulk of protein synthesis. However, several recent studies have demonstrated that CT and ET have similar roles in translational regulation. In a subset of mRNAs, CT preferentially drives the cap-dependent translation, as ET does, and ET is responsible for mRNA surveillance, as CT does. In this review, we summarize and compare the molecular features of CT and ET with a focus on the emerging roles of CT in translation.
Abstract, Accepted Manuscript(in press) [Submitted on January 16, 2017, Accepted on January 16, 2017]
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