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Tusc2/Fus1 regulates osteoclast differentiation through NF-kB and NFATc1
Inyoung Kim1, Jung Ha Kim1, Kabsun Kim1, Semun Seong1,2, Nacksung Kim1,2,*
1Pharmacology and 2Biomedical Sciences, Chonnam National University Medical School
Abstract
Tumor suppressor candidate 2 (Tusc2, also known as Fus1) regulates calcium signaling, and Ca2+-dependent nuclear factor of activated T-cells (NFAT) and nuclear factor kappa B (NF-kB) pathways, which play roles in osteoclast differentiation. However, the role of Tusc2 in osteoclasts remains unknown. Here, we report that Tusc2 positively regulates the differentiation of osteoclasts. Overexpression of Tusc2 in osteoclast precursor cells enhanced receptor of nuclear factor リB ligand (RANKL)-induced osteoclast differentiation. By contrast, small interfering RNA-mediated knockdown of Tusc2 strongly inhibited osteoclast differentiation. In addition, Tusc2 induced the activation of RANKL-mediated NF-kB and calcium/calmodulin-dependent kinase IV (CaMKIV)/cAMP-response element (CRE)-binding protein CREB signaling cascades. Taken together, these results suggest that Tusc2 acts as a positive regulator of RANKL-mediated osteoclast differentiation.
Abstract, Accepted Manuscript(in press) [Submitted on February 18, 2017, Accepted on April 3, 2017]
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