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Calcium-activated chloride channels as a new target to control the spiking pattern of neurons
Go Eun Ha1, Eunji Cheong1,*
1Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea
Abstract
Neuronal firing patterns and frequencies determine the nature of encoded information in the neural circuits. Here we discuss the molecular identity and cellular mechanisms of spike-frequency adaptation in central nervous system (CNS). Spike-frequency adaptation in thalamocortical (TC) and CA1 hippocampal neurons is mediated by the Ca2+-activated Cl- channel (CACC) anoctamin-2 (ANO2). Knockdown of ANO2 in these neurons results in significantly reduced spike-frequency adaptation along with increased number of spikes. No previous study has described the finding that CACCs mediate afterhyperpolarization currents, which result in the modulation of neuronal spike patterns in the central nervous system. Therefore, our study proposes a novel role for ANO2 in spike-frequency adaptation and transmission of information in the brain.
Abstract, Accepted Manuscript [Submitted on March 2, 2017, Accepted on March 2, 2017]
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