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Translational control of mRNAs by 3∏-untranslated region binding proteins
Akio Yamashita1, Osamu Takeuchi1,*
1Department of Molecular Biology, Yokohama City University School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan,
2Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
Abstract
Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3∏-untranslated regions (UTRs) of mRNAs. mRNA 3∏-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay. RNA binding proteins that bind to these cis-acting elements regulate mRNA translation via various mechanisms targeting the mRNA cap structure, the eukaryotic initiation factor 4E (eIF4E)-eIF4G complex, ribosomes, and the poly (A) tail. We also discuss translation-mediated regulation of mRNA fate.
Abstract, Accepted Manuscript(in press) [Submitted on March 8, 2017, Accepted on March 9, 2017]
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