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RNA at the heart of gene expression: Special issue of BMB Reports 2017
Yoon Ki Kim1,2,*
1Creative Research Initiatives Center for Molecular Biology of Translation and 2School of Life Sciences, Korea University, Seoul 02841, Republic of Korea
Abstract
Over the past several decades, our knowledge of RNAs has increased dramatically. In particular, the recent advances in next-generation sequencing, combined with crosslinking immunoprecipitation or other variants, has led to the expansion of a list of RNAs including long noncoding RNAs (lncRNAs) and small regulatory RNAs such as microRNAs, short interfering RNAs, and Piwi-interacting RNAs. Although only a small number of previously unappreciated RNA roles have begun to be revealed, it is a good time to introduce the recent RNA advances and their related functions to readers. This special issue on RNA invites three perspectives, five mini-reviews, and four research articles. The topics covered in this special issue include microRNA-mediated gene silencing, the molecular mechanism of nonsense-mediated mRNA decay (NMD), mRNA translation, mitochondrial noncoding RNA (ncRNA) transport, genome-wide analysis of ncRNAs, and alternative polyadenylation.
Abstract, Accepted Manuscript [Submitted on March 15, 2017, Accepted on March 15, 2017]
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