A challenge to oncogenic RAS target |
Chang Woo Han1, Mi Suk Jeong1, Se Bok Jang1,* |
1Department of Molecular Biology, Pusan National University |
Abstract
Mutations in Ras GTPase are among the most common genetic alterations in human cancers. Despite extensive research investigating Ras proteins, their functions still remain a challenge over a long period of time. The currently available data suggests that solving the outstanding issues regarding Ras could lead to development of effective drugs that could have a significant impact on cancer treatment. Developing a better understanding of their biochemical properties or modes of action, along with improvements in their pharmacologic profiles, clinical design and scheduling will enable the development of more effective therapies.
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Abstract, Accepted Manuscript(in press) [Submitted on April 13, 2017, Accepted on May 28, 2017] |
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