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A challenge to oncogenic RAS target
Chang Woo Han1, Mi Suk Jeong1, Se Bok Jang1,*
1Department of Molecular Biology, Pusan National University
Abstract
Mutations in Ras GTPase are among the most common genetic alterations in human cancers. Despite extensive research investigating Ras proteins, their functions still remain a challenge over a long period of time. The currently available data suggests that solving the outstanding issues regarding Ras could lead to development of effective drugs that could have a significant impact on cancer treatment. Developing a better understanding of their biochemical properties or modes of action, along with improvements in their pharmacologic profiles, clinical design and scheduling will enable the development of more effective therapies.
Abstract, Accepted Manuscript [Submitted on April 13, 2017, Accepted on May 28, 2017]
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