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This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

 
ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer
Xiaokun Wang1,2, Yan Xia2, Chentong Xu2, Xin Lin2, Peng Xue3, Shijie Zhu4, Yun Bai1, yingyu chen2,*
1 Department of Cell Biology and 2 Department of Immunology, School of Basic Medical Sciences, Peking University,
3College of China-Japan Friendship Hospital, Beijing University of Chinese Medicine,
4Oncology, Wangjing Hospital, China Academy of Chinese Medical Sciences
Abstract
Endoplasmic reticulum (ER) membrane protein complex subunit 6 (EMC6) is a novel human autophagy-related molecule. Here, using tissue microarray and immunohistochemistry, we report that EMC6 protein is lost or reduced in glandular cells of patients with gastric adenocarcinoma, compared to normal stomach mucosa. Overexpression of EMC6 in gastric cancer cells inhibited cell growth, migration, and invasion, and induced apoptosis and cell cycle arrest at S-phase. Further investigation suggested that EMC6 overexpression in BGC823 cells reduced tumorigenicity in a xenograft model, demonstrating that EMC6 has the characteristics of a tumor suppressor. This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored.
Abstract, Accepted Manuscript(in press) [Submitted on April 19, 2017, Accepted on June 23, 2017]
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