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Therapeutic implication of autophagy in neurodegenerative diseases
Md. Ataur Rahman1, Hyewhon Rhim1,*
1Center for Neuroscience, Korea Institute of Science and Technology, Seoul, Korea,
2Department of Neuroscience, Korea University of Science and Technology, Daejeon, Korea
Abstract
Autophagy, a catabolic process to maintain intracellular homeostasis, has been recently focus in numerous human disease conditions, such as aging, cancer, development, immunity, longevity, and neurodegeneration. However, sustaining autophagy is essential for cell survival and dysregulate autophagy is anticipated to speed up neurodegeneration progression; although, the actual molecular mechanism is not yet fully understood. In contrast, emerging evidence suggests that basal autophagy is necessary for removal of misfolded aggregation proteins and damaged cellular organelles through lysosomal mediated degradation. Physiologically, neurodegenerative disorders are related to the accumulation of amyloid モ peptide and メ-synuclein protein aggregation in Alzheimer disease and Parkinson disease, respectively. Even though autophagy could impact several facets of human biology and disease, however it functions as a clearance for toxic protein in the brain contributes us novel insight into the pathophysiological understanding of neurodegenerative disorder. In particular, several studies demonstrate that natural compounds or small molecule autophagy enhancer stimuluses autophagy which is essential in clearance amyloid モ and メ-synuclein deposits. Therefore, this review briefly deliberate the recent implication of autophagy in neurodegenerative disorder control and emphasize the opportunities and potential therapeutic application of autophagy.
Abstract, Accepted Manuscript(in press) [Submitted on April 28, 2017, Accepted on April 28, 2017]
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