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This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

Dual TORCs driven and B56 orchestrated Signaling Network guides eukaryotic cell migration
Lou W. Kim1,*
1Department of Biological Sciences, Florida International University, Miami, FL, USA 33199
Different types of eukaryotic cells may adopt seemingly distinct modes of directional cell migration. However, several core aspects are regarded common whether the movement is either ameoboidal or mesenchymal. The region of cells facing the attractive signal is often termed leading edge where lamellipodial structures dominates and the other end of the cell called rear end is often mediating cytoskeletal F-actin contraction involving Myosin-II. Dynamic remodeling of cell-to-matrix adhesion involving integrin is also evident in many types of migrating cells. All these three aspects of cell migration are significantly affected by signaling networks of TorC2, TorC1, and PP2A/B56. Here we review the current views of the mechanistic understanding of these regulatory signaling networks and how these networks affect eukaryotic cell migration.
Abstract, Accepted Manuscript(in press) [Submitted on May 31, 2017, Accepted on May 31, 2017]
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