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Transforming growth factor モ1 enhances adhesion of endometrial cells to mesothelium by regulating expression of integrins
Hee-Jung Choi1,2, Mi-Ju Park2, Bo-Sung Kim1,2,3, Hee-Jin Choi1,2,3, Bosun Joo2, Kyu Sup Lee4, Jung-Hye Choi5, Tae-Wook Chung1,2, Ki-Tae Ha1,*
1Department of Korean Medical Science and 2Healthy Aging Korean Medical Research Center and 3Graduate Training Program of Korean Medicine for Healthy-aging, Pusan National University,
4Department of Obstetrics & Gynecology, Pusan National University Hospital,
5Department of Life and Nanopharmaceutical Sciences and Department of Oriental Pharmacy, Kyung Hee University
Interestingly, transforming growth factor モ1 (TGF-モ1) expression was higher in endometriotic epithelial cells than in normal endometrial cells. The adhesion efficiency of endometriotic epithelial cells to mesothelial cells was also higher than that of normal endometrial cells. Moreover, TGF-モ1 directly induced the adhesion of endometrial cells to mesothelial cells through the regulation of integrin of メV, メ6, モ1, and モ4 via the activation of the TGF-モ1/TGF-モRI/Smad2 signaling pathway. Conversely, the adhesion of TGF-モ1-stimulated endometrial cells to mesothelial cells was clearly reduced following treatment with neutralizing antibodies against specific TGF-モ1-mediated integrins メV, モ1, and モ4 on the endometrial cell membrane. Taken together, our results demonstrate that secreted TGF-モ1 enhances the adhesion of endometrial cells to mesothelial cells by inducing the expression of integrin heterodimers メVモ1, メ6モ1, and メ6モ4 via the activation of the TGF-モRI/Smad2 signaling pathway, leading to endometriosis formation outside the uterus.
Abstract, Accepted Manuscript(in press) [Submitted on June 11, 2017, Accepted on July 31, 2017]
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