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Functional roles of CTCF in breast cancer
Sumin Oh1, Chaeun Oh1, Kyung Hyun Yoo1,*
1Research Institute of women’s health, Sookmyung Women’s University, Seoul, 04310, Republic of Korea,
2Laboratory of Biomedical Genomics, Department of Biological Sciences, Sookmyung Women’s University, Seoul, 04310, Republic of Korea
Abstract
CTCF, Zn-finger protein, has been identified as multifunctional transcription factor to regulate gene expression through recruitment of other co-activators and binding to promoter regions of target genes. Furthermore, it has been proposed as an insulator protein that contributes to the establishment of functional three-dimensional chromatin structures. It could disrupt transcription through block the connection between enhancer and promoter. Previous studies revealed that various diseases including breast cancer were developed from aberrant expression of CTCF itself or their target genes. In this review, we will describe dysfunction of CTCF that induces tumorigenesis and summarize the functional roles of CTCF in breast cancer.
Abstract, Accepted Manuscript [Submitted on June 26, 2017, Accepted on June 26, 2017]
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