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Suppression of SIRT2 and altered acetylation status of human pluripotent stem cells: possible link to metabolic switch during reprogramming
Ok-Seon Kwon1, Min-Joon Han1, Hyuk-Jin Cha1,*
1College of Natural Sciences, Dept. of Life Sciences, Sogang University, Seoul, 121-742, Korea,
2Department of Hematology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
Abstract
Primed human pluripotent stem cells (hPSCs) are highly dependent on glycolysis rather than oxidative phosphorylation, which is similar to the metabolic switch that occurs in cancer cells. However, the molecular mechanisms that underlie this metabolic reprogramming in hPSCs and its relevance to pluripotency remain unclear. Cha et al. (2017) recently revealed that downregulation of SIRT2 by miR-200c enhances acetylation of glycolytic enzymes and glycolysis, which in turn facilitates cellular reprogramming, suggesting that SIRT2 is a key enzyme linking the metabolic switch and pluripotency in hPSCs.
Abstract, Accepted Manuscript(in press) [Submitted on July 6, 2017, Accepted on July 6, 2017]
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