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CoMIC, the hidden dynamics of mitochondrial inner compartments
Bongki Cho1, Woong Sun1,*
1Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Korea,
2Department of Anatomy, Korea University College of Medicine, Seoul 02841, Korea
Abstract
Mitochondria have evolutionarily, functionally and structurally distinct outer- (OMM) and inner-membranes (IMM). Thus, mitochondrial morphology is controlled by independent but coordinated activity of fission and fusion of the OMM and IMM. Constriction and division of the OMM are mediated by endocytosis-like machineries, which include dynamin-related protein 1 with additional cytosolic vesicle scissoring machineries such as actin filament and Dynamin 2. However, structural alteration of the IMM during mitochondrial division has been poorly understood. Recently, we found that the IMM and the inner compartments undergo transient and reversible constriction prior to the OMM division, which we termed CoMIC, Constriction of Mitochondrial Inner Compartment. In this short review, we further discuss the evolutionary perspective and the regulatory mechanism of CoMIC during mitochondrial division.
Abstract, Accepted Manuscript(in press) [Submitted on August 8, 2017, Accepted on August 8, 2017]
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