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FGF Signaling: Diverse Roles During Cochlear Development
Michael Ebeid2, Sung-Ho Huh1,2,*
1Mary & Dick Holland Regenerative Medicine Program and 2Department of Developmental Neuroscience, Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, Nebraska
Mammalian inner ear comprises of six sensory organs; cochlea, utricle, saccule, and three semicircular canals. The cochlea contains sensory epithelium known as the organ of Corti which senses sound through mechanosensory hair cells. Mammalian inner ear undergoes series of morphogenesis during development by beginning thickening of ectoderm nearby hindbrain. These events require tight regulation of multiple signaling cascades including FGF, Wnt, Notch and Bmp signaling. In this review, we will discuss the role of newly emerging signaling, FGF signaling, for its roles required for cochlear development.
Abstract, Accepted Manuscript(in press) [Submitted on August 23, 2017, Accepted on August 23, 2017]
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