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HCBP6 upregulates human SREBP1c expression by binding to C/EBPモ-binding site in the SREBP1c promoter
Xueliang Yang1,#, Ming Han2,3,#, Shunai Liu3,4, Xiaoxue Yuan3,4, Xiaojing Liu1, Shenghu Feng2,3, Li Zhou2,3, Yaru Li3,4, Hongping Lu3,4, Jun Cheng2,3,4, Shumei Lin1,*
1Department of Infectious Diseases, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China,,
2Beijing Ditan Hospital, Peking University Teaching Hospital, Beijing 100015, China,,
3Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China,,
4Insitiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
Abstract
Sterol regulatory element-binding protein-1c (SREBP1c) plays an important role in triglyceride (TG) homeostasis. Although our previous study showed that hepatitis C virus core-binding protein 6 (HCBP6) regulates SREBP1c expression to maintain intracellular TG homeostasis, the mechanism underlying this regulation is unclear. In the present study, we found that HCBP6 increased intracellular TG levels by upregulating SREBP1c expression. HCBP6 increased SREBP1c transcription by directly binding to the SREBP1c promoter (at the -139- to +359-bp region). Moreover, we observed that HCBP6 interacted with C/EBPモ-binding site in the SREBP1c promoter both in vitro and in vivo. These results indicate that HCBP6 upregulates human SREBP1c expression by binding to the C/EBPモ-binding site in the SREBP1c promoter.
Abstract, Accepted Manuscript(in press) [Submitted on September 12, 2017, Accepted on November 20, 2017]
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