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Anti-inflammatory and anti-oxidative effects of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride on モ-amyloid-induced microglial activation
Seung-Ju Yang1, Jiae Kim2, Sang Eun Lee2, Jee-Yin Ahn3, Soo Young Choi4, Sung-Woo Cho2,*
1Department of Biomedical Laboratory Science, Konyang University,
2Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine,
3Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine,
4Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University
Abstract
We aimed to assess the anti-inflammatory and antioxidative properties of KHG26792, a novel azetidine derivative, in amyloid モ (Aモ)-treated primary microglial cells. KHG26792 attenuated the Aモ-induced production of inflammatory mediators such as IL-6, IL-1モ, TNF-メ, and nitric oxide. The levels of protein oxidation, lipid peroxidation, ROS, and NADHP oxidase enhanced by Aモ were also downregulated by KHG26792 treatment. The effects of KHG26792 against the Aモ-induced increases in inflammatory cytokine levels and oxidative stress were achieved by increasing the phosphorylation of Akt/GSK-3モ signaling and by decreasing the Aモ-induced translocation of NF-リB. Our results provide novel insights into the use of KHG26792 as a potential agent against Aモ toxicity, including its role in the reduction of inflammation and oxidative stress. Nevertheless, further investigations of cellular signaling are required to clarify the in vivo effects of KHG26792 against Aモ-induced toxicity.
Abstract, Accepted Manuscript(in press) [Submitted on September 22, 2017, Accepted on October 12, 2017]
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