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Early Potential Effects of Resveratrol Supplementation on Skeletal Muscle Adaptation Involved in Exercise-induced Weight Loss in Obese Mice
Jingyu Sun1,#, Chen Zhang2,#, MinJeong Kim3, Yajuan Su4, Lili Qin1, Jingmei Dong1, Yunhe Zhou1, Shuzhe Ding5,*
1Sports and Health Research Center, Department of Physical Education and 2School of Medicine, Tongji University,
3College of Medicine, Chung-Ang University,
4School of Life Sciences and Technology, Tongji University,
5Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, East China Normal University
Exercise and resveratrol supplementation exhibit anti-obesity functions in the long term but have not been fully investigated yet in terms of their early potential effectiveness. Mice fed with high-fat diet were categorized into control (Cont), exercise (Ex), resveratrol supplementation (Res), and exercise combined with resveratrol supplementation (Ex + Res) groups. In the four-week period of weight loss, exercise combined with resveratrol supplementation exerted no additional effects on body weight loss but significantly improved whole-body glucose and lipid homeostasis. The combined treatment significantly decreased intrahepatic lipid content but did not affect intramyocellular lipid content. Moreover, the treatment significantly increased the contents of mtDNA and cytochrome c, the expression levels of peroxisome proliferator-activated receptor gamma coactivator-1 alpha and its downstream transcription factors, and the activities of ATPase and citrate synthase. However, exercise, resveratrol, and their combination did not promote myofiber specification toward slow-twitch type. The effects of exercise combined with resveratrol supplementation on weight loss could be partly due to enhanced mitochondrial biogenesis and not to fiber-type shift in skeletal muscle tissues.
Abstract, Accepted Manuscript(in press) [Submitted on December 27, 2017, Accepted on March 2, 2018]
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