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Integration of metabolomics and transcriptomics in nanotoxicity studies
Tae Hwan Shin1, Da Yeon Lee1, Hyeon-Seong Lee1, Hyung Jin Park1, Moon Suk Jin1, Man-Jeong Paik1, Balachandran Manavalan1, Jung-Soon Mo1, Gwang Lee1,*
1Institute of Molecular Science and Technology, Ajou University, Republic of Korea,
2Department of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea,
3College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea,
4Genomic Instability Research Center, Ajou University School of Medicine, Suwon, Republic of Korea
Biomedical research involving nanoparticles has produced useful products with medical applications. However, the potential toxicity of nanoparticles in biofluids, cells, tissues, and organisms is a major challenge. The ‘-omics’ analyses provide molecular profiles of multifactorial biological systems instead of focusing on a single molecule. The ‘omics’ approaches are necessary to evaluate nanotoxicity because classical methods for the detection of nanotoxicity have limited ability in detecting miniscule variations within a cell and do not accurately reflect the actual levels of nanotoxicity. In addition, the ‘omics’ approaches allow analyses of in-depth changes and compensate for the differences associated with high-throughput technologies between actual nanotoxicity and results from traditional cytotoxic evaluations. However, compared with a single omics approach, integrated omics provides precise and sensitive information by integrating complex biological conditions. Thus, these technologies contribute to extended safety evaluations of nanotoxicity and allow the accurate diagnoses of diseases far earlier than was once possible in the nanotechnology era. Here, we review a novel approach for evaluating nanotoxicity by integrating metabolomics with metabolomic profiling and transcriptomics, which is termed “metabotranscriptomics.”
Abstract, Accepted Manuscript(in press) [Submitted on December 28, 2017, Accepted on December 28, 2017]
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