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Human amnion-derived mesenchymal stem cells induced osteogenesis and angiogenesis in human adipose-derived stem cells via ERK1/2 MAPK signaling pathway
Yuli Wang1,3, Xichen Chen4, Ying Yin5, Song Li1,2,*
1Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.,
2Department of Periodontology and 3Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.,
4Analysis Center, Nanjing Medical University, Nanjing, China.,
5Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China
Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs. In this study, we investigated the effect of HAMSCs on HASCs by a transwell co-culture system. HAMSCs promoted proliferation, osteogenic differentiation, angiogenic potential and adiponectin (APN) secretion of HASCs. Moreover, the positive effect of HAMSCs was significantly inhibited by U0126, a highly selective inhibitor of extracellular signaling-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signaling pathway. These observations suggested that HAMSCs induced bone regeneration in HASCs via ERK1/2 MAPK signaling pathway.
Abstract, Accepted Manuscript(in press) [Submitted on January 11, 2018, Accepted on February 6, 2018]
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