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Long noncoding RNA: multiple players in gene expression
Xiaochang Chen1, Yunmei Sun1, Rui Cai1, Guoqiang Wang1, Xiaoyan Shu2, Weijun Pang1,*
1Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University,
2School of Life Science and Engineering, Southwest University of Science and Technology
Previously considered as a component of transcriptional noise, long noncoding RNAs ( lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and post-transcriptional regulation. In this review, we discuss the fundamental functions of lncRNAs at different regulatory levels and their roles in metabolic balance. Typical examples are introduced to illustrate their diverse molecular mechanisms. The comprehensive investigation and identification of key lncRNAs will not only contribute to insights into diseases, such as breast cancer and type II diabetes, but also provide promising therapeutic targets for related diseases.
Abstract, Accepted Manuscript(in press) [Submitted on February 5, 2018, Accepted on April 4, 2018]
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