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Potential roles of reactive oxygen species derived from chemical substances in the cancer development of female reproductive system
Soo-Min Kim1, Kyung-A Hwang1, Kyung-Chul Choi1,*
1College of Veterinary Medicine, Chungbuk National University
Abstract
The reactive oxygen species (ROS) are major sources of cellular oxidative stress. Specifically, cancer cells harbor genetic alterations that promote a continuous and elevated production of ROS. Whereas such oxidative stress conditions would be harmful to normal cells, they facilitate cancer cell growth in multiple ways by causing DNA damage and genomic instability, and ultimately, by reprogramming cancer cell metabolism. This review provides the reader with up to date most relevant findings on the role of ROS generation induced by diverse biological molecules and chemicals in women’s representative cancer. Specifically, we describe the cellular signaling pathways that regulate direct or indirect interactions between ROS homeostasis and metabolism within female genital cancer cells.
Abstract, Accepted Manuscript(in press) [Submitted on March 18, 2018, Accepted on June 18, 2018]
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