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Activation of formyl peptide receptor 2 by WKYMVm enhances emergency granulopoiesis through phospholipase C activity
Yoe-Sik Bae1,3,*, Hyung Sik Kim1, Min Young Park1, Sung Kyun Lee1, Joon Seong Park2, Ha Young Lee1
1Biological Sciences, Sungkyunkwan University,
2Hematology-Oncology, Ajou University School of Medicine,
3Health Sciences and Technology, Sungkyunkwan University
Abstract
Emergency granulopoiesis is very important strategy to supply efficient neutrophil number in response to infection. However, molecular mechanism involved in the process remains unclear. Here, we found that administration of WKYMVm, an immune modulating peptide, to septic mice strongly increased neutrophil number through augmented emergency granulopoiesis. WKYMVm-induced emergency granulopoiesis was blocked not only by a formyl peptide receptor 2 (FPR2) antagonist (WRW4) but also by FPR2 deficiency. Progenitors of neutrophils, Lin-c-kit+Sca-1- cells express FPR2, and WKYMVm-induced emergency granulopoieis was also blocked by a PLC inhibitor (U-73122). Given these results, we suggest that WKYMVm stimulates emergency granulopoiesis via FPR2 and PLC enzymatic activity.
Abstract, Accepted Manuscript(in press) [Submitted on April 13, 2018, Accepted on July 3, 2018]
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