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Protective effects of Tat-DJ-1 protein against streptozotocin (STZ)-induced diabetes in a mice model
Soo Young Choi1,*, Hyeon Ji Yeo1, Eun Ji Yeo1, Min Jea Shin1, Yeon Joo Choi1, Chi Hern Lee1, Hyeok Yil Kwon1, Dae Won Kim1, Won Sik Eum1, Soo Young Choi1
1Biomedical Science and Research Institute of Bioscience and Biotechnology and 2Physiology, College of Medicine, Hallym University,
3Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University
Abstract
A major feature of type 1 diabetes mellitus is hyperglycemia and dysfunction of pancreatic モ-cells. In a previous study, we showed that Tat-DJ-1 protein inhibits pancreatic RINm5F モ-cell death caused by oxidative stress. In this study, we examine the effects of Tat-DJ-1 protein on streptozotocin (STZ)-induced diabetic mice. Wild type (WT) Tat-DJ-1 protein transduced into pancreas where it markedly inhibited pancreatic モ-cell destruction and regulated the level of serum parameters including insulin, alkaline phosphatase (ALP), and free fatty acid (FFA) secretion. In addition, transduced WT Tat-DJ-1 protein significantly inhibited the activation of NF-リB and MAPK (ERK and p38) expression as well as COX-2 and iNOS expression in STZ exposed pancreas. In contrast, there were no protective effects of treatment with C106A mutant Tat-DJ-1 protein. Collectively our results indicate that WT Tat-DJ-1 protein significantly ameliorates pancreatic tissues in STZ exposed diabetic mice.
Abstract, Accepted Manuscript(in press) [Submitted on May 2, 2018, Accepted on June 1, 2018]
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