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MiR-363 inhibits cisplatin chemoresistance of epithelial ovarian cancer by regulating Snail-induced epithelial–mesenchymal transition
Lanqin Cao1, Qian Wan1, Fengjie Li1, can-e Tang2,*,#
1Department of Obstetrics and 2The Institute of Medical Science Research, Xiangya Hospital, Central South University
Abstract
Chemoresistance is a major barrier to successful cisplatin-based chemotherapy for epithelial ovarian cancer (EOC), and emerging evidences suggest that microRNAs (miRNAs) are involved in the resistance. In this study, it was indicated that miR-363 downregulation was significantly correlated with EOC carcinogenesis and cisplatin resistance. Moreover, miR-363 overexpression could resensitise cisplatin-resistant EOC cells to cisplatin treatment both in vitro and in vivo. In addition, data revealed that EMT inducer Snail was significantly upregulated in cisplatin-resistant EOC cell lines and EOC patients and was a functional target of miR-363 in EOC cells. Furthermore, snail overexpression could significantly attenuate miR-363-suppressed cisplatin resistance of EOC cells, suggesting that miR-363-regulated cisplatin resistance is mediated by snail-induced EMT in EOC cells. Taken together, findings suggest that miR-363 may be a biomarker for predicting responsiveness to cisplatin-based chemotherapy and a potential therapeutic target in EOC.
Abstract, Accepted Manuscript(in press) [Submitted on May 8, 2018, Accepted on July 20, 2018]
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