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Exosomes Derived from MicroRNA-584 Transfected Mesenchymal Stem Cells: Novel Alternative Therapeutic Vehicles for Cancer Therapy
Ran Kim1, Seokyeon Lee1, Jihyun Lee1, Minji Kim1, Won Jung Kim1, Hee Won Lee1, Min Young Lee2, Jongmin Kim3, Woochul Chang1,*
1Department of Biology Education, Pusan National University,
2Department of Molecular Physiology, Kyungpook National University,
3Department of Life Systems, Sookmyung Women’s University
Abstract
Exosomes are small membranous vesicles which contain abundant RNA molecules, and are transferred from releasing cells to uptaking cells. MicroRNA (miRNA) is one of the transferred molecules affecting the adopted cells, including glioma cells. We hypothesized that mesenchymal stem cells (MSCs) can secrete exosomes loading miRNA and have important effects on the progress of gliomas. To determine these effects by treating exosomal miRNA in culture media of miRNA mimic transfected MSCs, we assessed the in vitro cell proliferation and invasion capabilities, and the expression level of relative proteins associated with cell apoptosis, growth and migration. For animal studies, the mice injected with U87 cells were exposed to exosomes derived from miRNA-584-5p transfected MSCs, to confirm the influence of exosomal miRNA on the progress of glioma. Based on our results, we propose a new targeted cancer therapy wherein exosomes derived from miRNA transfected MSCs could be used to modulate tumor progress as the anticancer vehicles.
Abstract, Accepted Manuscript(in press) [Submitted on May 8, 2018, Accepted on June 27, 2018]
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