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Mitochondria-mediated defense mechanisms against pathogens in Caenorhabditis elegans
Sujeong Kwon1, Eun Ji E. Kim1, Seung-Jae V. Lee1,*
1Department of Life Sciences and 2Department of Information Technology Convergence Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea
Abstract
Mitochondria are crucial organelles that generate cellular energy and metabolites. Recent studies indicate that mitochondria also regulate immunity. In this review, we discuss key roles of mitochondria in immunity against pathogen infection and underlying mechanisms, focusing on discoveries using Caenorhabditis elegans. Various mitochondrial processes, including mitochondrial surveillance mechanisms, mitochondrial unfolded protein response (UPRmt), mitophagy, and reactive oxygen species (ROS) production, contribute to immune responses and resistance of C. elegans against pathogens. Biological processes of C. elegans are usually conserved across phyla. Thus, understanding the mechanisms of mitochondria-mediated defense responses in C. elegans may provide insights into similar mechanisms in complex organisms, including mammals.
Abstract, Accepted Manuscript [Submitted on May 16, 2018, Accepted on May 16, 2018]
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