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Cancer stem cell metabolism: target for cancer therapy
Young Chan Chae1, Jae Ho Kim1,*
1School of Life Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea,
2Department of Physiology, School of Medicine, Pusan National University, Yangsan 50621, Republic of Korea,
3Research Institute of Convergence Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50621, Republic of Korea
Abstract
Increasing evidence suggests that cancer stem cell (CSC) theory represents an important mechanism underlying the observed failure of existing therapeutic modalities to fully eradicate cancers. In addition to their more established role in maintaining minimal residual disease after treatment and forming the new bulk of the tumor, CSCs might also critically contribute to tumor recurrence and metastasis. For this reason, specific elimination of CSCs may thus represent one of the most important treatment strategies. Emerging evidence has shown that CSCs have a different metabolic phenotype to that of differentiated bulk tumor cells, and these specific metabolic activities directly participate in the process of CSC transformation or support the biological processes that enable tumor progression. Exploring the role of CSC metabolism and the mechanism of the metabolic plasticity of CSCs has become a major focus in current cancer research. The targeting of CSC metabolism may provide new effective therapies to reduce the risk of recurrence and metastasis. In this review, we summarize the most significant discoveries regarding the metabolism of CSCs and highlight recent approaches in targeting CSC metabolism.
Abstract, Accepted Manuscript [Submitted on May 16, 2018, Accepted on May 16, 2018]
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