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Down-regulated microRNAs in colorectal cancer: diagnostic and therapeutic perspectives
Rosa Hernández1,2,3, Ester Sánchez-Jiménez4, Consolación Melguizo1,2,3, Jose Prados1,2,3,*, Ana R Rama1,5
1Institute of Biopathology and Regenerative Medicine (IBIMER),, Granada University,
2Biosanitary Institute of Granada (ibs. GRANADA), SAS-Universidad de Granada,
3Department of Human Anatomy and Embryology, University of Granada,
4Proteomics Laboratory CSIC/UAB, Institute of Biomedical Research Barcelona,
5Department of Health Science, University of Jaén
Abstract
Colorectal cancer (CRC), the third most common cancer in the world, has no specific biomarkers that facilitate its diagnosis and subsequent treatment. MicroRNAs, small single-stranded RNAs that repress mRNA translation and trigger mRNA degradation, show aberrant levels in CRC by which these molecules have been related with the initiation, progression and drug-resistance of this cancer type. Numerous studies have shown that miRNAs influence cellular mechanisms related to cell cycle, differentiation, apoptosis and migration of cancer cells through post-transcriptionally regulate gene expression. Specific patterns of upregulated and down-regulated miRNA have been associated to CRC diagnosis, prognosis and therapeutic response. Concretely, down-regulated microRNAs represent attractive candidates, not only for CRC diagnosis, but for targeted therapies via tumor suppressor micro RNA replacement. This review shows a general overview of the potential uses of miRNAs in CRC diagnosis, prognosis, treatment with a special focus on down-regulated ones.
Abstract, Accepted Manuscript(in press) [Submitted on May 24, 2018, Accepted on July 10, 2018]
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