BMB Reports Papers in Press available online.

Search Papers In Press
This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

 
With the greatest care, stromal interaction molecule (STIM) proteins verify what skeletal muscle is doing
Chung-Hyun Cho1, Keon Jin Lee1, Eun Hui Lee1,*
1Department of Pharmacology, College of Medicine, Seoul National University, Seoul 08826, Korea,
2Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
Abstract
Skeletal muscle contracts or relaxes to maintain the body position and locomotion. For the contraction and relaxation of skeletal muscle, Ca2+ in the cytosol of skeletal muscle fibers acts as a switch to turn on and off a series of contractile proteins. The cytosolic Ca2+ level in skeletal muscle fibers is governed mainly by movement of Ca2+ between the cytosol and the sarcoplasmic reticulum (SR). Store-operated Ca2+ entry (SOCE), a Ca2+ entryway from the extracellular space to the cytosol, has gained a significant amount of attention from muscle physiologists. Orai1 and stromal interaction molecule 1 (STIM1) are the main protein identities of SOCE. This mini-review focuses on the roles of STIM proteins and SOCE in the physiological and pathophysiological functions of skeletal muscle and in their correlations with recently identified proteins, as well as historical proteins that are known to mediate skeletal muscle function.
Abstract, Accepted Manuscript(in press) [Submitted on June 14, 2018, Accepted on June 14, 2018]
  Copyright © KSBMB. All rights reserved. / Powered by INFOrang.co., Ltd