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Potential involvement of Drosophila flightless-1 in carbohydrate metabolism
Jung-Eun Park1,#, Jinho Jang2,#, Eun Ji Lee1, Su Jung Kim3, Hyun Ju Yoo3, Semin Lee2, Min Ji Kang1,*
1Department of Biomedical Sciences, University of Ulsan College of Medicine,
2Department of Biological Engineering, Ulsan National Institute of Science and Technology,
3Department of Convergence Medicine, University of Ulsan College of Medicine
Our previous study indicates that Drosophila Flightless-1 controls lipid metabolism, and that there is accumulation of triglycerides in flightless-1 (fliI)-mutant flies, where this mutation triggers metabolic stress and an obesity phenotype. Here, with the aim to characterize the function of FliI in metabolism, we analyzed the gene expression and levels of metabolites in fliI-mutant flies. The levels of enzymes related to glycolysis, lipogenesis, and the pentose phosphate pathway increased in fliI mutants; this result is consistent with the levels of metabolites corresponding to a metabolic pathway. Moreover, high-throughput RNA sequencing revealed that Drosophila FliI regulates the expression of genes related to biological processes including chromosome organization, carbohydrate metabolism, and immune reactions. These results showed that Drosophila FliI regulates expression of metabolic genes, and dysregulation of the transcription controlled by FliI gives rise to metabolic stress and to problems in Drosophila development and physiology.
Abstract, Accepted Manuscript(in press) [Submitted on July 10, 2018, Accepted on July 25, 2018]
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