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MiR-371 Promotes Proliferation and Metastasis in Hepatocellular Carcinoma by Targeting PTEN
Hao Wang1,#, Yi Zhao1,#, Tingsong Chen2, Guofang Liu1, Nan He3, Heping Hu1,*
1Eastern Hepatobiliary Surgery Hospital (EHBH), Second Military Medical University, Eastern Hepatobiliary Surgery Hospital (EHBH), Second Military Medical University,
2The Seventh People’s Hospital of Shanghai, The Seventh People’s Hospital of Shanghai,
3Guangdong Ascendas Genomics Technology Co., Ltd., Guangdong Ascendas Genomics Technology Co., Ltd.
Abstract
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality worldwide. MiR-371 recently emerged as an important regulator in tumorigenesis, and might serve as a biomarker for malignant tumors. We transfected miR-371 or its inhibitor in two human HCC cell lines, and used 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, soft agar colony formation and transwell migration assays to evaluate its effect on cell proliferation, migration and invasion. We found miR-371 was positively correlated with HCC metastasis and poor prognosis of the inflicted patients, and high expression of miR-371 promoted, whereas low level of miR-371 depressed cell proliferation and invasion. We found PTEN to be a direct target of miR-371. Overexpression or knockdown of PTEN exhibited opposite effect compared to those of miR-371 on cell proliferation and migration. Our study demonstrates that miR-371 promotes proliferation and metastasis in HCC by targeting PTEN.
Abstract, Accepted Manuscript(in press) [Submitted on July 19, 2018, Accepted on September 19, 2018]
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