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SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker
Liyun Xu1,*, Changchang Lu1, Yanyan Huang1, Jihang Zhou1, Xincheng Wang1, Chaowu Liu1, Jun Chen1, Hanbo Le1
11Cell and Molecular Biology Laboratory, Affiliated Zhoushan Hospital of Wenzhou Medical University
Abstract
Serine protease inhibitor Kazal type 1 (SPINK1) plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cells growth, migration and invasion. Mechanistically, we found that SPINK1 promoted LAC cells migration and invasion via up-regulating matrix metalloproteinase 12 (MMP12). We observed that SPINK1 expression was only up-regulated in lung adenocarcinoma (LAC) tissues, and was an independent prognostic factor for poor survival.Our results indicate that SPINK1 might be a potential biomarker for LAC that promotes progression by MMP12.
Abstract, Accepted Manuscript(in press) [Submitted on September 4, 2018, Accepted on November 15, 2018]
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