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Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition
Lian Xu1, Mengxia Fu1, Dongrui Chen1, Weiqing Han1, Michael C. Ostrowski2, Paul Grossfeld3, Pingjin Gao1, Maoqing Ye1,*
1Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Hypertension,
2Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, Ohio State University,
3Division of Pediatric Cardiology, University of California San Diego School of Medicine
Abstract
Cardiac fibrosis is a common feature in chronic hypertension patients with advanced heart failure, and endothelial-to-mesenchymal transition (EndMT) is known to promote Angiotensin II (Ang II)-mediated cardiac fibrosis. Previous studies have suggested a potential role for the transcription factor, ETS-1, in Ang II-mediated cardiac remodeling, however the mechanism are not well defined. In this study, we found that mice with endothelial Ets-1 deletion showed reduced cardiac fibrosis and hypertrophy following Ang II infusion. The reduced cardiac fibrosis was accompanied by decreased expression of fibrotic matrix genes, reduced EndMT with decreased Snail, Slug, Twist, and ZEB1 expression, as well as reduced cardiac hypertrophy and expression of hypertrophy-associated genes was observed. In vitro studies using cultured H5V cells further confirmed that ETS-1 knockdown inhibited TGF-モ1-induced EndMT. This study revealed that deletion of endothelial Ets-1 attenuated Ang II-induced cardiac fibrosis via inhibition of EndMT, indicating an important ETS-1 function in mediating EndMT. Inhibition of ETS-1 could be a potential therapeutic strategy for treatment of heart failure secondary to chronic hypertension.
Abstract, Accepted Manuscript(in press) [Submitted on September 7, 2018, Accepted on January 14, 2019]
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