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Tat-ATOX1 Inhibits Inflammatory Responses via Regulation of MAPK and NF-リB pathways
Soo Young Choi1,*, Dae Won Kim2, Min Jea Shin1, Yeon Joo Choi1, Hyun Jung Kwon2, Sung Ho Lee3, Sunghou Lee4, Jinseu Park1, Kyu Hyung Han1, Won Sik Eum1
1Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University,
2Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University,
3R&D Center, Lumieye Genetics Co., Ltd.,
4Green Chemical Engineering, Sangmyung University
Abstract
Antioxidant 1 (ATOX1) protein has been reported to exhibit various protective functions including antioxidant and chaperone. However, the effects of ATOX1 on inflammatory response remains to be elucidated. Thus, we prepared cell permeable Tat-ATOX1 and studied the effects on lipopolysaccharide (LPS)- and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced inflammation. Experimental results showed that transduced Tat-ATOX1 protein significantly suppressed LPS-induced intracellular reactive oxygen species (ROS) and DNA fragmentation. Also, Tat-ATOX1 protein markedly inhibited LPS- and TPA-induced inflammatory responses by decreasing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and further inhibited phosphorylation of mitogen activated protein kinases (MAPKs; JNK, ERK and p38) and the nuclear factor-kappaB (NF-リB) signaling pathway. Those results indicate that Tat-ATOX1 protein acts a pivotal role in inflammation via inhibition of inflammatory responses, suggesting Tat-ATOX1 protein may offer a therapeutic strategy to inflammation.
Abstract, Accepted Manuscript(in press) [Submitted on October 26, 2018, Accepted on November 21, 2018]
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