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This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

 
Juxtacrine regulation of cellular senescence
Masashi Narita1,*
1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK
Abstract
Cellular senescence is defined as a state of stable cell cycle exit in response to various stimuli, which includes both cytotoxic stress and physiological cues. In addition to the core non-proliferative aspect, senescence is associated with diverse functionalities, which contribute to the role of senescence in a wide range of pathological and physiological processes. Such functionality is often mediated by the capability of senescent cells to communicate with their surroundings. Emerging evidence suggests that senescence is not a single entity, but a dynamic and heterogeneous collective phenotype. Understanding the diverse nature of senescence should provide insights into the complexity of tissue homeostasis and its disruption, such as in aging and tumorigenesis.
Abstract, Accepted Manuscript [Submitted on December 10, 2018, Accepted on December 10, 2018]
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