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Metabolic features and regulation in cell senescence
Gyesoon Yoon1,*, So Mee Kwon1, Sun Mi Hong1, Young-Kyoung Lee1, Seongki Min1
1Department of Biochemistry and Department of Biomedical Sciences (BK21 Plus), Ajou University School of Medicine, Suwon, 16499, Korea
Organismal aging is accompanied by a host of progressive metabolic alterations and an accumulation of senescent cells, along with functional decline and the appearance of multiple diseases. This implies that the metabolic features of cell senescence may contribute to the organism’s metabolic changes and be closely linked to age-associated diseases, especially metabolic syndromes. However, there is no clear understanding of senescent metabolic characteristics. Here, we review key metabolic features and regulators of cellular senescence, focusing on mitochondrial dysfunction and anabolic deregulation, and their link to other senescence phenotypes and aging. We further discuss the mechanistic involvement of the metabolic regulators mTOR, AMPK, and GSK3, proposing them as key metabolic switches for modulating senescence.
Abstract, Accepted Manuscript [Submitted on December 10, 2018, Accepted on December 10, 2018]
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