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Multi-level remodeling of transcriptional landscapes in aging and longevity
Bérénice A. Benayoun1,3,4,*, Rochelle Lai1, Ryan Lu1, Prakroothi S. Danthi1, Juan Bravo1,2, Alexandre Goumba1, Nirmal Kumar Sampathkumar1
1Leonard Davis School of Gerontology and 2Graduate program in the Biology of Aging, University of Southern California, Los Angeles, CA 90089, USA,
3USC Norris Comprehensive Cancer Center, Epigenetics and Gene Regulation, Los Angeles, CA 90089, USA,
4USC Stem Cell Initiative, Los Angeles, CA 90089, USA
In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and gene expression has been observed to be deregulated with aging. In this review, we discuss the current knowledge on the transcriptional alterations that have been described to occur with age in metazoans. First, we discuss age-related transcriptional changes in protein-coding genes, the expected functional impact of such changes, and how known pro-longevity interventions impact these changes. Second, we discuss the changes and impact of emerging aspects of transcription in aging, including age-related changes in splicing, lncRNAs and circRNAs. Third, we discuss the changes and potential impact of transcription of transposable elements with aging. Fourth, we highlight small ncRNAs and their potential impact on the regulation of aging phenotypes. Understanding the aging transcriptome will be key to identify important regulatory targets, and ultimately slow-down or reverse aging and extend healthy lifespan in humans.
Abstract, Accepted Manuscript [Submitted on December 10, 2018, Accepted on December 10, 2018]
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