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Growth Signaling and Longevity in Mouse Models
Cheol-Koo Lee1,2,*, Seung-Soo Kim1
1Institute of Animal Molecular Biotechnology, Korea University, Seoul 02841, Republic of Korea,
2Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02481, Republic of Korea
Abstract
Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) extends the lifespan of various species. So far, several longevity mouse models have been developed containing mutations related to growth signaling deficiency by targeting growth hormone (GH), IGF1, IGF1 receptor, insulin receptor, and insulin receptor substrate. In addition, p70 ribosomal protein S6 kinase 1 (S6K1) knockout leads to lifespan extension. S6K1 encodes an important kinase in the regulation of cell growth. S6K1 is regulated by mechanistic target of rapamycin (mTOR) complex 1. The v-myc myelocytomatosis viral oncogene homolog (MYC)-deficient mice also exhibits a longevity phenotype. The gene expression profiles of these mice models have been measured to identify their longevity mechanisms. Here, we summarize our knowledge of long-lived mouse models related to growth and discuss phenotypic characteristics, including organ-specific gene expression patterns.
Abstract, Accepted Manuscript [Submitted on December 13, 2018, Accepted on December 13, 2018]
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