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The coordinated regulation of mitochondrial structure and function by Drp1 for mitochondrial quality surveillance
Woong Sun1,*, Hyo Min Cho1
1Department of Anatomy, Korea University College of Medicine, Brain Korea 21 plus, Seoul 02841, Republic of Korea
Abstract
Mitochondrial morphology is known to be continuously changing via fusion and fission, but it is unclear what the biological importance of this energy-consuming process is and how it develops. Several data have suggested that mitochondrial fission executed by Drp1 is necessary to select out a damaged spot from the interconnected mitochondrial network, but the precise mechanism for the recognition and isolation of a damaged sub-mitochondrial region during mitochondrial fission is yet unclear. Recently, Cho et al. found that the characteristic mitochondrial membrane potential (MMP) is transiently reduced by the physical interaction of Drp1 and mitochondrial Zinc transporter, Zip1, at the fission site prior to the typical mitochondrial division, and we found that this event is essential for a mitochondrial quality surveillance. In this review, Cho et al. discuss the role of a mitochondrial fission in the mitochondrial quality surveillance system.
Abstract, Accepted Manuscript [Submitted on January 30, 2019, Accepted on January 30, 2019]
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