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Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS- and TPA-induced damages
Soo Young Choi1,*, Hyeon Ji Yeo1, Min Jea Shin1, Ji Ho You1, Jeong Su Kim1, Min Young Kim1, Dae Won Kim2, Duk-Soo Kim3, Won Sik Eum1
1Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University,
2Biochemistry and Molecular Biology, Gangneung-Wonju National University,
3Anatomy, College of Medicine, Soonchunhyang University
Cytokine-induced apoptosis inhibitor 1 (CIAPIN1), known as anti-apoptotic and signal transduction protein, plays a pivotal role in a variety of biological progresses. However, the role of CIAPIN1 in inflammation is unclear. We investigated the protective effects of CIAPIN1 in lipopolysaccharide (LPS)-exposed Raw 264.7 cells and protection of CIAPIN1 against inflammatory damage induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse model using cell permeable Tat-CIAPIN1. Transduced Tat-CIAPIN1 significantly reduced ROS production and DNA fragmentation in LPS-exposed Raw 264.7 cells. Also, Tat-CIAPIN1 inhibited MAPKs and NF-リB activation as well as reduced the expression of Bax, cleaved caspase-3, COX-2, iNOS, IL-6 and TNF-メ in LPS-exposed the cells. In a TPA-induced animal model, transduced Tat-CIAPIN1 drastically decreased inflammation damage and inhibited COX-2, iNOS, IL-6, and TNF-メ expression. Therefore, these findings suggest Tat-CIAPIN1 might lead to a new strategy for the treatment of inflammatory skin disorders.
Abstract, Accepted Manuscript(in press) [Submitted on October 14, 2019, Accepted on October 21, 2019]
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